Addressing the Health Care issues for Romney in the 2012 race will be paramount.
Though I'm pretty sure Mitt will do a better job of "staying on message" during this run than in 2008, he will need to address his history of Health Care reform (e.g. Romneycare) to some degree.
Part 1 of the series is titled Mitt Romney vs. Health Care: “The Problem” (Or is it?)
Part 2: Mitt Romney vs. Health Care: “Why RomneyCare Makes Mitt the BEST Nominee to Face Obama”
And a recent update showing that Mitt's not taking the bait on a call that he "apologize" for RomneyCare . . . "Mitt Owning RomneyCare . . . No Apology"